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Glossary
- Apoptosis
- Cell death in which the cell uses specialized cellular machinery to kill itself.
- Angiogenesis
- The formation of new blood vessels.
- DNA
- Deoxyribonucleic acid. The basic building blocks of each organism’s genetic code.
- GAPDH
- Glyceraldehyde-3-Phosphate Dehydrogenase, an important enzyme in the pathways cells use to generate energy to survive.
- IND
- Investigational New Drug application, submitted to the United States Food and Drug Administration (FDA) prior to the start of human clinical trials to demonstrate safety and efficacy. This application contains the results of animal pharmacology and toxicology studies, information about the manufacturing process, clinical protocols and investigator information.
- Iodothyronine
- A globular protein that is the basic structural constituent of microtubules.
- NDA (New Drug Application)
- A large document that is filed with the United States Food and Drug Administration (FDA) requesting approval for a proposed therapy. This document is filed once all clinical testing is completed and results have been analyzed. It contains all of the information relating to the proposed drug, including adverse events and details on the manufacturing process.
- Oncogenes
- Genes which can potentially induce changes in new cell growths, including cancerous changes.
- PARP
- Poly ADP-Ribose Polymerase, a ubiquitous enzyme found in cells, is involved in early DNA damage recognition and repair.
- PARP inhibitors
- A class of drugs that inhibits the production of PARP and therefore leads to cell death as the cell cannot repair DNA damage and will not replicate successfully.
